Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy

Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy

Expression of androgen receptor (AR) splice variant 7 (AR-V7) has been identified as the mechanism associated with the development of castration-resistant prostate cancer (CRPC). However, a potential link between AR-V7 expression and resistance to taxanes, such as docetaxel or cabazitaxel, has not b...

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Bibliographic Details
Main Authors: Yasuomi Shimizu, Satoshi Tamada, Minoru Kato, Yukiyoshi Hirayama, Yuji Takeyama, Taro Iguchi, Marianne D. Sadar, Tatsuya Nakatani
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Journal of Clinical Medicine
Subjects:
androgen receptor
docetaxel
cabazitaxel
castration-resistant prostate cancer
chemotherapy
P-glycoprotein
EPI-002
splice variant
Online Access:https://www.mdpi.com/2077-0383/7/11/444

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https://www.mdpi.com/2077-0383/7/11/444

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