Heterogeneous mutation pattern in tumor tissue and circulating tumor DNA warrants parallel NGS panel testing

Heterogeneous mutation pattern in tumor tissue and circulating tumor DNA warrants parallel NGS panel testing

Abstract Liquid biopsy by genotyping circulating tumor DNA (ctDNA) has provided a non-invasive approach in assessing tumor genomic alterations in clinical oncology. However, emerging evidence in clinical settings has shown significant discordance in the genomic alterations between matched tumor tiss...

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Bibliographic Details
Main Authors: Qiaomei Guo, Junlei Wang, Jianfeng Xiao, Lin Wang, Xiaomeng Hu, Wenjun Yu, Gang Song, Jiatao Lou, JianFeng Chen
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
Liquid biopsy
Circulating tumor DNA
NGS,non-small-cell lung cancer
Somatic mutations
Concordance
Online Access:http://link.springer.com/article/10.1186/s12943-018-0875-0

Internet

http://link.springer.com/article/10.1186/s12943-018-0875-0

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