Design and synthesis of 5-methylpyrazine-2-carbohydrazide derivatives: A new anti-tubercular scaffold

A simple synthetic methodology was employed for synthesis of series of 5-methylpyrazine-2-carbohydrazide derivatives (PM series). In vitro anti-tubercular activity was evaluated against Mycobacterium tuberculosis (H37Rv) in Middle brook 7H-9 broth medium. Amongst synthesized compounds, seven compoun...

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Bibliographic Details
Main Authors: P.B. Miniyar, S.N. Mokale, S.J. Makhija
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535213000907