Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo
Chaperone mediated autophagy (CMA) is selective but its activity in different tissue types has been unclear due to a lack of tools. Here, the authors generate transgenic mice expressing a CMA reporter that provides spatial and temporal in vivo data, uncovering differences in CMA in distinct tissues.
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-14164-4 |