A genetic model of ivabradine recapitulates results from randomized clinical trials.

A genetic model of ivabradine recapitulates results from randomized clinical trials.

<h4>Background</h4>Naturally occurring human genetic variants provide a valuable tool to identify drug targets and guide drug prioritization and clinical trial design. Ivabradine is a heart rate lowering drug with protective effects on heart failure despite increasing the risk of atrial...

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Main Authors: Marc-André Legault, Johanna Sandoval, Sylvie Provost, Amina Barhdadi, Louis-Philippe Lemieux Perreault, Sonia Shah, R Thomas Lumbers, Simon de Denus, Benoit Tyl, Jean-Claude Tardif, Marie-Pierre Dubé
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236193

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https://doi.org/10.1371/journal.pone.0236193

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