The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of Reaction to Low Ca2+ Concentrations

The Structure of Ca2+ Sensor Case16 Reveals the Mechanism of Reaction to Low Ca2+ Concentrations

Here we report the first crystal structure of a high-contrast genetically encoded circularly permuted green fluorescent protein (cpGFP)-based Ca2+ sensor, Case16, in the presence of a low Ca2+ concentration. The structure reveals the positioning of the chromophore within Case16 at the first stage of...

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Bibliographic Details
Main Authors: Lydia A. Strukova, Dmitriy M. Chudakov, Olga V. Britanova, Lorenz M. Mayr, Thomas Stettler, Marco Meyerhofer, Felix Freuler, May Marsh, Wilhelm Stark, Ekaterina A. Souslova, Lukas Leder
Format: Article
Language:English
Published: MDPI AG 2010-08-01
Series:Sensors
Subjects:
circularly permuted green fluorescent protein
genetically encoded
fluorescent calcium indicator protein
crystal structure
calcium sensor
Online Access:http://www.mdpi.com/1424-8220/10/9/8143/

Internet

http://www.mdpi.com/1424-8220/10/9/8143/

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