Circadian control of brain glymphatic and lymphatic fluid flow

Circadian control of brain glymphatic and lymphatic fluid flow

Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.

Bibliographic Details
Main Authors: Lauren M. Hablitz, Virginia Plá, Michael Giannetto, Hanna S. Vinitsky, Frederik Filip Stæger, Tanner Metcalfe, Rebecca Nguyen, Abdellatif Benrais, Maiken Nedergaard
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18115-2

Internet

https://doi.org/10.1038/s41467-020-18115-2

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