Circadian control of brain glymphatic and lymphatic fluid flow

Circadian control of brain glymphatic and lymphatic fluid flow

Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.

Bibliographic Details
Main Authors: Lauren M. Hablitz, Virginia Plá, Michael Giannetto, Hanna S. Vinitsky, Frederik Filip Stæger, Tanner Metcalfe, Rebecca Nguyen, Abdellatif Benrais, Maiken Nedergaard
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18115-2
id doaj-52b023d7976d45dea43058d42e720d90
record_format Article
spelling doaj-52b023d7976d45dea43058d42e720d902021-09-05T11:45:22ZengNature Publishing GroupNature Communications2041-17232020-09-0111111110.1038/s41467-020-18115-2Circadian control of brain glymphatic and lymphatic fluid flowLauren M. Hablitz0Virginia Plá1Michael Giannetto2Hanna S. Vinitsky3Frederik Filip Stæger4Tanner Metcalfe5Rebecca Nguyen6Abdellatif Benrais7Maiken Nedergaard8Center for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterGlymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.https://doi.org/10.1038/s41467-020-18115-2
collection DOAJ
language English
format Article
sources DOAJ
author Lauren M. Hablitz
Virginia Plá
Michael Giannetto
Hanna S. Vinitsky
Frederik Filip Stæger
Tanner Metcalfe
Rebecca Nguyen
Abdellatif Benrais
Maiken Nedergaard
spellingShingle Lauren M. Hablitz
Virginia Plá
Michael Giannetto
Hanna S. Vinitsky
Frederik Filip Stæger
Tanner Metcalfe
Rebecca Nguyen
Abdellatif Benrais
Maiken Nedergaard
Circadian control of brain glymphatic and lymphatic fluid flow
Nature Communications
author_facet Lauren M. Hablitz
Virginia Plá
Michael Giannetto
Hanna S. Vinitsky
Frederik Filip Stæger
Tanner Metcalfe
Rebecca Nguyen
Abdellatif Benrais
Maiken Nedergaard
author_sort Lauren M. Hablitz
title Circadian control of brain glymphatic and lymphatic fluid flow
title_short Circadian control of brain glymphatic and lymphatic fluid flow
title_full Circadian control of brain glymphatic and lymphatic fluid flow
title_fullStr Circadian control of brain glymphatic and lymphatic fluid flow
title_full_unstemmed Circadian control of brain glymphatic and lymphatic fluid flow
title_sort circadian control of brain glymphatic and lymphatic fluid flow
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-09-01
description Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.
url https://doi.org/10.1038/s41467-020-18115-2
work_keys_str_mv AT laurenmhablitz circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT virginiapla circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT michaelgiannetto circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT hannasvinitsky circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT frederikfilipstæger circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT tannermetcalfe circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT rebeccanguyen circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT abdellatifbenrais circadiancontrolofbrainglymphaticandlymphaticfluidflow
AT maikennedergaard circadiancontrolofbrainglymphaticandlymphaticfluidflow
_version_ 1717813969104666624

Similar Items