Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

IFN-γ release assays [e.g., QuantiFERON (QFT)] are widely used for diagnosis of Mycobacterium tuberculosis (Mtb) infection. T-cell responses against QFT antigens ESAT6 and CFP10 are highly Mtb specific but previous studies indicated suboptimal assay sensitivity. Especially for potentially infected h...

Full description

Bibliographic Details
Main Authors: Ernest Adankwah, Christian Lundtoft, Alptekin Güler, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Ertan Mayatepek, Ellis Owusu-Dabo, Richard Odame Phillips, Norman Nausch, Marc Jacobsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
LTBI
IGRA
Mycobacterium tuberculosis latency antigens
ESAT6
CFP10
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01518/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01518/full

Similar Items