Beneficial Role of Rosuvastatin in Blood–Brain Barrier Damage Following Experimental Ischemic Stroke

Beneficial Role of Rosuvastatin in Blood–Brain Barrier Damage Following Experimental Ischemic Stroke

Hemorrhage transformation is the most challenging preventable complication in thrombolytic therapy and is related to recombinant tissue plasminogen activator (rt-PA)-induced blood–brain barrier (BBB) damage. Intraperitoneal injections of normal or high doses of rosuvastatin were administered to Balb...

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Bibliographic Details
Main Authors: Dan Lu, Hong-Cheng Mai, Yu-Bin Liang, Bing-Dong Xu, An-Ding Xu, Yu-Sheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
tissue type plasminogen activator therapy
blood–brain barrier
rosuvastatin
tight junction protein
matrix metalloproteinase
focal cerebral ischemia
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00926/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00926/full

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