Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects

Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects

Interferon regulatory factor 5 (IRF5) is widely recognized as a risk locus for systemic lupus erythematosus (SLE). Risk gene and IRF5 activation is triggered through toll-like receptor signaling. In myeloid cells, this leads to production of type I interferon and inflammatory cytokines, with enhance...

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Bibliographic Details
Main Authors: Justine Calise, Susana Marquez Renteria, Peter K. Gregersen, Betty Diamond
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
genetics
B lymphocytes
monocytes
haplotypes
autoimmunity
lupus
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00996/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00996/full

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