Pharmacological induction of the heat shock response improves myelination in a neuropathic model

Pharmacological induction of the heat shock response improves myelination in a neuropathic model

Misexpression and intracellular retention of peripheral myelin protein 22 (PMP22) is associated with hereditary neuropathies in humans, including Charcot–Marie–Tooth disease type 1A (CMT1A). Mice expressing extra copies of the human PMP22, termed C22, display morphologic and behavioral characteristi...

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Bibliographic Details
Main Authors: Sunitha Rangaraju, Irina Madorsky, Jocelyn Go Pileggi, Adeela Kamal, Lucia Notterpek
Format: Article
Language:English
Published: Elsevier 2008-10-01
Series:Neurobiology of Disease
Subjects:
CMT1A neuropathy
Demyelination
Schwann cells
Protein misfolding
Heat shock response
Heat shock proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001381

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http://www.sciencedirect.com/science/article/pii/S0969996108001381

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