Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset

Preclinical Study of DNA-Recognized Peptide Compound Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Progressive Renal Diseases in the Common Marmoset

Pyrrole-imidazole (PI) polyamides are novel gene silencers that strongly bind the promoter region of target genes in a sequence-specific manner to inhibit gene transcription. We created a PI polyamide targeting human TGF-β1 (hTGF-β1). To develop this PI polyamide targeting hTGF-&am...

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Bibliographic Details
Main Authors: Masari Otsuki, Noboru Fukuda, Takashi Inoue, Takayuki Mineshige, Tomoyasu Otsuki, Shu Horikoshi, Morito Endo, Masanori Abe
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
human
TGF-β1
pyrrole-imidazole polyamide
renal disease
marmoset
Online Access:https://www.mdpi.com/1420-3049/24/17/3178

Internet

https://www.mdpi.com/1420-3049/24/17/3178

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