Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase

Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase

The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released transmitter glutamate/GABA to neurons after astrocytic uptake. This review deals primarily with the glutamate/GABA generation/oxi...

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Bibliographic Details
Main Authors: Leif Hertz, Douglas L Rothman
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Biology
Subjects:
aspartate aminotransferase
astrocyte culture
brain metabolism
glutamate-glutamine cycle
glutamate dehydrogenase
glutamate oxidation
glutamine synthetase
malate-aspartate shuttle
metabolic compartmentation
nitrogen balance
Online Access:http://www.mdpi.com/2079-7737/6/1/17

Internet

http://www.mdpi.com/2079-7737/6/1/17

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