Gadd45β ameliorates L-DOPA-induced dyskinesia in a Parkinson's disease mouse model

The dopamine precursor 3,4-dihydroxyphenyl-l-alanine (L-DOPA) is currently the most efficacious pharmacotherapy for Parkinson's disease (PD). However, long-term L-DOPA treatment leads to the development of abnormal involuntary movements (AIMs) in patients and animal models of PD. Recently, invo...

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Main Authors: Hye-Yeon Park, Young-Kyoung Ryu, Yong-Hoon Kim, Tae-Shin Park, Jun Go, Jung Hwan Hwang, Dong-Hee Choi, Myungchull Rhee, Chul-Ho Lee, Kyoung-Shim Kim
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300341