Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

It has been proposed that deregulation of neuronal glycogen synthase kinase 3 (GSK3) activity may be a key feature in Alzheimer disease pathogenesis. We have previously generated transgenic mice that overexpress GSK3β in forebrain regions including dentate gyrus (DG), a region involved in learning a...

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Bibliographic Details
Main Authors: Elena Gómez de Barreda, Mar Pérez, Pilar Gómez Ramos, Javier de Cristobal, Patricia Martín-Maestro, Asunción Morán, Hana N. Dawson, Michael P. Vitek, José J. Lucas, Félix Hernández, Jesús Avila
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer disease
Dentate gyrus
GSK-3
tau
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109003398

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http://www.sciencedirect.com/science/article/pii/S0969996109003398

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