IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells

IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells

CD8+ T cells are involved in the pathogenesis of multiple sclerosis (MS). The interleukin-2 receptor α (IL-2Rα) is important for CD8+ T cell function, and single nucleotide polymorphisms (SNPs) in the IL2RA gene encoding IL-2Rα increase the risk of MS. Therefore, in isolated CD8+ T cells we investig...

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Bibliographic Details
Main Authors: Sophie Buhelt, Hannah-Marie Laigaard, Marina Rode von Essen, Henrik Ullum, Annette Oturai, Finn Sellebjerg, Helle Bach Søndergaard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
CD8+ T cells
interleukin-2 receptor alpha
sCD25
IL2RA
rs2104286
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.676141/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.676141/full

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