The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.

Sepsis and septic shock are associated with high mortality rates and the majority of sepsis patients die due to complications of multiple organ failure (MOF). The cyclic GMP (cGMP) producing enzyme soluble guanylate cyclase (sGC) is crucially involved in the regulation of (micro)vascular homeostasis...

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Bibliographic Details
Main Authors: Benjamin Vandendriessche, Elke Rogge, Vera Goossens, Peter Vandenabeele, Johannes-Peter Stasch, Peter Brouckaert, Anje Cauwels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756074?pdf=render

Internet

http://europepmc.org/articles/PMC3756074?pdf=render

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