Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

Lomerizine 2HCl inhibits cell proliferation and induces protective autophagy in colorectal cancer via the PI3K/Akt/mTOR signaling pathway

Abstract Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, the survival and response rates in CRC patients are still poor. In our previous study, a library comprised of 1056 bioactive compounds was used for screening of drugs that could s...

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Bibliographic Details
Main Authors: Xiang‐Peng Tan, Yan He, Yun‐Na Huang, Can‐Can Zheng, Jun‐Qi Li, Qin‐Wen Liu, Ming‐Liang He, Bin Li, Wen‐Wen Xu
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:MedComm
Subjects:
colorectal cancer
drug repurposing
lomerizine 2HCl
PI3K/Akt/mTOR signaling pathway
protective autophagy
Online Access:https://doi.org/10.1002/mco2.83

Internet

https://doi.org/10.1002/mco2.83

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