Mechanical load-induced H2S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1

Mechanical load-induced H2S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1

Abstract Background Tooth movement is a unique bone remodeling process induced by mechanical stimulation. Macrophages are important in mediating inflammatory processes during mechanical load-induced tooth movement. However, how macrophages are regulated under mechanical stimulation remains unclear....

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Bibliographic Details
Main Authors: Danqing He, Fuliang Liu, Shengjie Cui, Nan Jiang, Huajie Yu, Yanheng Zhou, Yan Liu, Xiaoxing Kou
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Stem Cell Research & Therapy
Subjects:
Stem cells
Macrophage polarization
Hydrogen sulfide
Bone remodeling
Mechanical load
Cell signaling
Online Access:http://link.springer.com/article/10.1186/s13287-020-01607-9

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http://link.springer.com/article/10.1186/s13287-020-01607-9

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