netSmooth: Network-smoothing based imputation for single cell RNA-seq [version 2; referees: 2 approved]
Single cell RNA-seq (scRNA-seq) experiments suffer from a range of characteristic technical biases, such as dropouts (zero or near zero counts) and high variance. Current analysis methods rely on imputing missing values by various means of local averaging or regression, often amplifying biases inher...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2018-01-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-8/v2 |