A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome

A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome

Dry eye syndrome is the most common eye disease and it is caused by various reasons. As the balance of the tear film that protects the eyes is broken due to various causes, it becomes impossible to properly protect the eyes. In this study, the protective effects and underlying mechanisms of topical...

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Bibliographic Details
Main Authors: Yoon-Ju Na, Kyoung Jin Choi, Won Hoon Jung, Sung Bum Park, Sein Kang, Jin Hee Ahn, Ki Young Kim
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
dry eye syndrome
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)
reactive oxygen species (ROS)
Online Access:https://www.mdpi.com/1422-0067/21/10/3729

Internet

https://www.mdpi.com/1422-0067/21/10/3729

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