SC-535, a Novel Oral Multikinase Inhibitor, Showed Potent Antitumor Activity in Human Melanoma Models

SC-535, a Novel Oral Multikinase Inhibitor, Showed Potent Antitumor Activity in Human Melanoma Models

Background: Melanoma is considered as one of the most aggressive and deadliest cancers and current targeted therapies of melanoma often suffer limited efficacy or drug resistance. Discovery of novel multikinase inhibitors as anti-melanoma drug candidates is still needed. Methods: In this investigati...

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Bibliographic Details
Main Authors: Xin Chen, Pan Ji, Hui-Wen Yang, Ling-Ling Yang, Shu Zhou, Lei Zhong, Shuang Ma, Xiao-Yu Fu, Chan Zhou, Guo-Bo Li, Ming-Wu Zheng, Yu-Quan Wei, Sheng-Yong Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
SC-535
BRAF
CRAF
G2/M phase cell cycle arrest
Antiangiogenesis
Online Access:http://www.karger.com/Article/FullText/350123

Internet

http://www.karger.com/Article/FullText/350123

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