PLS3 Mutations Cause Severe Age and Sex-Related Spinal Pathology

PLS3 Mutations Cause Severe Age and Sex-Related Spinal Pathology

Objective: Mutations in the X-chromosomal PLS3-gene, encoding Plastin 3, lead to severe early-onset osteoporosis, suggesting a major role for PLS3 in bone metabolism. However, the consequences of abnormal PLS3 function in bone and other tissues remain incompletely characterized. This study evaluated...

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Bibliographic Details
Main Authors: Riikka E. Mäkitie, Tuukka Niinimäki, Maria Suo-Palosaari, Anders Kämpe, Alice Costantini, Sanna Toiviainen-Salo, Jaakko Niinimäki, Outi Mäkitie
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Endocrinology
Subjects:
PLS3
magnetic resonance imaging
vertebral compression fracture
schmorl node
intervertebral disc
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00393/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00393/full

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