Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior

Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior

The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype. The association of TREK-1 with the sorting protein sortilin prompted us to investigate the behavior of mice de...

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Bibliographic Details
Main Authors: Sébastien Moreno, Christelle M. Devader, Mariel Pietri, Marc Borsotto, Catherine Heurteaux, Jean Mazella
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
depression
sortilin
TREK-1
behavior
electrophysiology
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00863/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00863/full

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