Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells

Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells

Dendritic cells (DC) are professional Antigen-Presenting Cells scattered throughout antigen-exposed tissues and draining lymph nodes, and survey the body for pathogens. Their ability to migrate through tissues, a 3D environment, is essential for an effective immune response. Upon infection, recognit...

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Bibliographic Details
Main Authors: Céline Cougoule, Claire Lastrucci, Romain Guiet, Rémi Mascarau, Etienne Meunier, Geanncarlo Lugo-Villarino, Olivier Neyrolles, Renaud Poincloux, Isabelle Maridonneau-Parini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
dendritic cells
podosomes
3D migration
toll-like receptor
maturation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00846/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00846/full

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