The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Abstract Background Our previous genome-wide association study using the MA.27 aromatase inhibitors adjuvant trial identified SNPs in the long noncoding RNA MIR2052HG associated with breast cancer-free interval. MIR2052HG maintained ERα both by promoting AKT/FOXO3-mediated ESR1 transcription and by...

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Bibliographic Details
Main Authors: Junmei Cairns, James N. Ingle, Krishna R. Kalari, Lois E. Shepherd, Michiaki Kubo, Matthew P. Goetz, Richard M. Weinshilboum, Liewei Wang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Breast Cancer Research
Subjects:
Lon noncoding RNA
MIR2052HG
EGR1
LMTK3
PKC
ERα
Online Access:http://link.springer.com/article/10.1186/s13058-019-1130-3

Internet

http://link.springer.com/article/10.1186/s13058-019-1130-3

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