Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease

Discovery of New Cyclopentaquinoline Analogues as Multifunctional Agents for the Treatment of Alzheimer’s Disease

Here we report the two-step synthesis of 8 new cyclopentaquinoline derivatives as modifications of the tetrahydroacridine structure. Next, the biological assessment of each of them was performed. Based on the obtained results we identified 6-chloro-<i>N</i>-[2-(2,3-dihydro-<i>1H<...

Full description

Bibliographic Details
Main Authors: Kamila Czarnecka, Małgorzata Girek, Paweł Kręcisz, Robert Skibiński, Kamil Łątka, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Ireneusz Majsterek, Piotr Szymczyk, Paweł Szymański
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholinesterase inhibitors
Alzheimer’s disease
molecular modeling
beta amyloid
yeast three-hybrid technology (Y3H) test
Online Access:https://www.mdpi.com/1422-0067/20/3/498

Internet

https://www.mdpi.com/1422-0067/20/3/498

Similar Items