Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder.

Systemic delivery of siRNA down regulates brain prion protein and ameliorates neuropathology in prion disorder.

One of the main challenges for neurodegenerative disorders that are principally incurable is the development of new therapeutic strategies, which raises important medical, scientific and societal issues. Creutzfeldt-Jakob diseases are rare neurodegenerative fatal disorders which today remain incurab...

Full description

Bibliographic Details
Main Authors: Sylvain Lehmann, Aroa Relano-Gines, Sarah Resina, Elsa Brillaud, Danielle Casanova, Charles Vincent, Claire Hamela, Sophie Poupeau, Mathieu Laffont, Audrey Gabelle, Constance Delaby, Maxime Belondrade, Jacques-Damien Arnaud, Maria-Teresa Alvarez, Jean-Claude Maurel, Patrick Maurel, Carole Crozet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3925167?pdf=render

Internet

http://europepmc.org/articles/PMC3925167?pdf=render

Similar Items