Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1 +/−−deficient mouse

Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1 +/−−deficient mouse

Abstract This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1 +/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected non-sensory deficits associated with Neurog1 heterozygosity, indicating that co...

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Bibliographic Details
Main Authors: Aleta R. Steevens, Matthew W. Griesbach, Yun You, James R. Dutton, Walter C. Low, Peter A. Santi
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Stem Cell Research & Therapy
Subjects:
Inner ear
Spiral ganglion neurons
Neurogenin1
Blastocyst complementation
Stem cells
Regenerative medicine
Online Access:https://doi.org/10.1186/s13287-021-02184-1

Internet

https://doi.org/10.1186/s13287-021-02184-1

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