Generation of inner ear sensory neurons using blastocyst complementation in a Neurog1 +/−−deficient mouse
Abstract This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1 +/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected non-sensory deficits associated with Neurog1 heterozygosity, indicating that co...
Main Authors: | Aleta R. Steevens, Matthew W. Griesbach, Yun You, James R. Dutton, Walter C. Low, Peter A. Santi |
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Format: | Article |
Language: | English |
Published: |
BMC
2021-02-01
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Series: | Stem Cell Research & Therapy |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13287-021-02184-1 |
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