Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice

Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice

Summary: An artificial tool for manipulating local cerebral blood flow (CBF) is necessary for understanding how CBF controls brain function. Here, we generate vascular optogenetic tools whereby smooth muscle cells and endothelial cells express optical actuators in the brain. The illumination of chan...

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Bibliographic Details
Main Authors: Yoshifumi Abe, Soojin Kwon, Mitsuhiro Oishi, Miyuki Unekawa, Norio Takata, Fumiko Seki, Ryuta Koyama, Manabu Abe, Kenji Sakimura, Kazuto Masamoto, Yutaka Tomita, Hideyuki Okano, Hajime Mushiake, Kenji F. Tanaka
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
optogenetics
cerebral blood flow
smooth muscle cell
endothelial cell
channelrhodopsin 2
photoactivated adenylyl cyclase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721008445

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http://www.sciencedirect.com/science/article/pii/S2211124721008445

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