PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

Abstract Background Aberrant changes in epigenetic mechanisms such as histone modifications play an important role in cancer progression. PRMT1 which triggers asymmetric dimethylation of histone H4 on arginine 3 (H4R3me2a) is upregulated in human colorectal cancer (CRC) and is essential for cell pro...

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Bibliographic Details
Main Authors: Bing Yao, Tao Gui, Xiangwei Zeng, Yexuan Deng, Zhi Wang, Ying Wang, Dongjun Yang, Qixiang Li, Peipei Xu, Ruifeng Hu, Xinyu Li, Bing Chen, Jin Wang, Ke Zen, Haitao Li, Melissa J. Davis, Marco J. Herold, Hua-Feng Pan, Zhi-Wei Jiang, David C. S. Huang, Ming Liu, Junyi Ju, Quan Zhao
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Medicine
Subjects:
Transcription
Epigenomics
H4R3me2s
PRMT1
SMARCA4
Colorectal Cancer
Online Access:https://doi.org/10.1186/s13073-021-00871-5

Internet

https://doi.org/10.1186/s13073-021-00871-5

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