Imaging CAR T-cell kinetics in solid tumors: Translational implications

Imaging CAR T-cell kinetics in solid tumors: Translational implications

Summary: Success in solid tumor chimeric antigen receptor (CAR) T-cell therapy requires overcoming several barriers, including lung sequestration, inefficient accumulation within the tumor, and target-antigen heterogeneity. Understanding CAR T-cell kinetics can assist in the interpretation of therap...

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Bibliographic Details
Main Authors: Matthew S. Skovgard, Hocine R. Hocine, Jasmeen K. Saini, Maxim Moroz, Rebecca Y. Bellis, Srijita Banerjee, Aurore Morello, Vladimir Ponomarev, Jonathan Villena-Vargas, Prasad S. Adusumilli
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
CAR T cells
in vivo imaging
immunotherapy
imaging reporter
lung cancer
mesothelioma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521000851

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http://www.sciencedirect.com/science/article/pii/S2372770521000851

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