Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons.
The striking differences between the clinical symptoms of tetanus and botulism have been ascribed to the different fate of the parental neurotoxins once internalised in motor neurons. Tetanus toxin (TeNT) is known to undergo transcytosis into inhibitory interneurons and block the release of inhibito...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-12-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3531519?pdf=render |