Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

Cholesterol-oximes TRO19622 and TRO40303 target outer mitochondrial membrane proteins and have beneficial effects in preclinical models of neurodegenerative diseases leading to their advancement to clinical trials. Dopaminergic neurons degenerate in Parkinson's disease (PD) and are prone to oxi...

Full description

Bibliographic Details
Main Authors: Franziska Richter, Fuying Gao, Vera Medvedeva, Patrick Lee, Nicholas Bove, Sheila M. Fleming, Magali Michaud, Vincent Lemesre, Stefano Patassini, Krystal De La Rosa, Caitlin K. Mulligan, Pedrom C. Sioshansi, Chunni Zhu, Giovanni Coppola, Thierry Bordet, Rebecca M. Pruss, Marie-Françoise Chesselet
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Transcriptome analysis
Laser capture microdissection
Neuroprotection
Alpha-synuclein
Transgenic mice
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001302

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114001302

Similar Items