Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity.

BACKGROUND:T cell receptor (TCR) engagement leads to formation of signaling microclusters and induction of rapid and dynamic changes in the actin cytoskeleton, although the exact mechanism by which the TCR initiates actin polymerization is incompletely understood. The Vav family of guanine nucleotid...

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Main Authors: Ana V Miletic, Daniel B Graham, Kumiko Sakata-Sogawa, Michio Hiroshima, Michael J Hamann, Saso Cemerski, Tracie Kloeppel, Daniel D Billadeau, Osami Kanagawa, Makio Tokunaga, Wojciech Swat
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2719804?pdf=render

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http://europepmc.org/articles/PMC2719804?pdf=render

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