Photosensitizer Activation Drives Apoptosis by Interorganellar Ca<sup>2+</sup> Transfer and Superoxide Production in Bystander Cancer Cells

Photosensitizer Activation Drives Apoptosis by Interorganellar Ca<sup>2+</sup> Transfer and Superoxide Production in Bystander Cancer Cells

In cells, photosensitizer (PS) activation by visible light irradiation triggers reactive oxygen species (ROS) formation, followed by a cascade of cellular responses involving calcium (Ca<sup>2+</sup>) and other second messengers, resulting in cell demise. Cytotoxic effects spread to near...

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Bibliographic Details
Main Authors: Chiara Nardin, Chiara Peres, Flavia Mazzarda, Gaia Ziraldo, Anna Maria Salvatore, Fabio Mammano
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
bystander effect
organellar ca<sup>2+</sup>
ros
mitochondria
endoplasmic reticulum
biosensors
photodynamic therapy
Online Access:https://www.mdpi.com/2073-4409/8/10/1175

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https://www.mdpi.com/2073-4409/8/10/1175

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