Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease

Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease

RNA interference (RNAi)-based strategies that mediate the specific knockdown of target genes by administration of small interfering RNAs (siRNAs) could be applied for treatment of presently incurable neurodegenerative diseases such as Parkinson’s disease. However, inefficient delivery of siRNA into...

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Bibliographic Details
Main Authors: Christin Helmschrodt, Sabrina Höbel, Sandra Schöniger, Anne Bauer, Jana Bonicelli, Marieke Gringmuth, Simone A. Fietz, Achim Aigner, Angelika Richter, Franziska Richter
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA interference
nanoparticles
intracerebroventricular
α-synuclein
mouse model
Parkinson’s disease
transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S216225311730241X

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http://www.sciencedirect.com/science/article/pii/S216225311730241X

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