Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.

Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.

Predicting how pathogen populations will change over time is challenging. Such has been the case with Streptococcus pneumoniae, an important human pathogen, and the pneumococcal conjugate vaccines (PCVs), which target only a fraction of the strains in the population. Here, we use the frequencies of...

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Bibliographic Details
Main Authors: Taj Azarian, Pamela P Martinez, Brian J Arnold, Xueting Qiu, Lindsay R Grant, Jukka Corander, Christophe Fraser, Nicholas J Croucher, Laura L Hammitt, Raymond Reid, Mathuram Santosham, Robert C Weatherholtz, Stephen D Bentley, Katherine L O'Brien, Marc Lipsitch, William P Hanage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000878

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https://doi.org/10.1371/journal.pbio.3000878

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