Synthesis, DNA-Binding and Antiproliferative Properties of Acridine and 5-Methylacridine Derivatives

Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by competitive dialysis and compared with the an...

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Bibliographic Details
Main Authors: Ramon Eritja, Rubén Ferreira, Stefania Mazzini, Anna Aviñó
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Molecules
Subjects:
NMR
Online Access:http://www.mdpi.com/1420-3049/17/6/7067