Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?

Effect of Type 2 Diabetes Mellitus on the Hypoxia-Inducible Factor 1-Alpha Expression. Is There a Relationship with the Clock Genes?

Limited reports exist on the relationships between regulation of oxygen homeostasis and circadian clock genes in type 2 diabetes. We examined whether the expression of Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α relates to changes in the expression of clock genes (Period homolog proteins (PER)1,...

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Bibliographic Details
Main Authors: Carolina López-Cano, Liliana Gutiérrez-Carrasquilla, Ferran Barbé, Enric Sánchez, Marta Hernández, Raquel Martí, Vicky Ceperuelo-Mallafre, Mireia Dalmases, Sonia Fernández-Veledo, Joan Vendrell, Cristina Hernández, Rafael Simó, Albert Lecube
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Journal of Clinical Medicine
Subjects:
type 2 diabetes
hypoxia
metabolic control
chronodisruption
clock genes
Online Access:https://www.mdpi.com/2077-0383/9/8/2632

Internet

https://www.mdpi.com/2077-0383/9/8/2632

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