Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria

Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria

BackgroundCerebral malaria (CM) is characterized by the sequestration of Plasmodium-infected erythrocytes (pRBCs) to host brain microvasculature beds via P. falciparum erythrocyte membrane protein 1 (PfEMP1). Under normal conditions, activated protein C (APC) bound to endothelial protein C receptor...

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Bibliographic Details
Main Authors: Juan Carlos Cespedes, Jacqueline Hibbert, Sri Krishna, Fengxia Yan, Praveen K. Bharti, Jonathan K. Stiles, Mingli Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Genetics
Subjects:
cerebral malaria
endothelial protein C receptor
activated protein C
pathogenesis
polymorphism
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00056/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00056/full

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