Pharmacogenetics to Avoid Loss of Hearing (PALOH) trial: a protocol for a prospective observational implementation trial

Pharmacogenetics to Avoid Loss of Hearing (PALOH) trial: a protocol for a prospective observational implementation trial

Introduction In conjunction with a beta-lactam, aminoglycosides are the first-choice antibiotic for empirical treatment of sepsis in the neonatal period. The m.1555A>G variant predisposes to ototoxicity after aminoglycoside administration and has a prevalence of 1 in 500. Current genetic test...

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Main Authors: Richard Body, Mark A Turner, William G Newman, John Henry McDermott, Gino Miele, Peter Roberts, Fiona Ulph, Rhona MacLeod, Shaun Ainsworth, Rachel Mahood, Duncan Stoddard, Ajit Mahaveer, Rachel Corry, Julia Garlick, Laura Kemp, Karen Harvey, Nicola Booth
Format: Article
Language:English
Published: BMJ Publishing Group 2021-06-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/11/6/e044457.full

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https://bmjopen.bmj.com/content/11/6/e044457.full

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