A prospective multicenter phase II study on the efficacy and safety of dasatinib in the treatment of metastatic gastrointestinal stromal tumors failed by imatinib and sunitinib and analysis of NGS in peripheral blood

Abstract Aim Dasatinib is a small molecule tyrosine kinase inhibitor with multiple targets including kit, PDGFR, and SRC. This prospective study evaluated the efficacy and safety of dasatinib as third‐line treatment for gastrointestinal stromal tumors (GIST). Methods The study enrolled adult patient...

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Bibliographic Details
Main Authors: Ye Zhou, Xinhua Zhang, Xiaojun Wu, Yongjian Zhou, Bo Zhang, Xiufeng Liu, Xin Wu, Yan Li, Lin Shen, Jian Li
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Cancer Medicine
Subjects:
Online Access:https://doi.org/10.1002/cam4.3319