Combined Pharmacophore Modeling, 3D-QSAR, Homology Modeling and Docking Studies on CYP11B1 Inhibitors

Combined Pharmacophore Modeling, 3D-QSAR, Homology Modeling and Docking Studies on CYP11B1 Inhibitors

The mitochondrial cytochrome P450 enzymes inhibitor steroid 11β-hydroxylase (CYP11B1) can decrease the production of cortisol. Therefore, these inhibitors have an effect in the treatment of Cushing’s syndrome. A pharmacophore model generated by Genetic Algorithm with Linear Assignment for Hypermolec...

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Bibliographic Details
Main Authors: Rui Yu, Juan Wang, Rui Wang, Yong Lin, Yong Hu, Yuanqiang Wang, Mao Shu, Zhihua Lin
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Molecules
Subjects:
CYP11B1 inhibitors
3D-QSAR
pharmacophore model
Cushing’s syndrome
Online Access:http://www.mdpi.com/1420-3049/20/1/1014

Internet

http://www.mdpi.com/1420-3049/20/1/1014

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