Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Activation of Multiple ERBB Family Receptors Mediates Glioblastoma Cancer Stem-like Cell Resistance to EGFR-Targeted Inhibition

Epidermal growth factor receptor (EGFR) signaling is strongly implicated in glioblastoma (GBM) tumorigenesis. However, molecular agents targeting EGFR have demonstrated minimal efficacy in clinical trials, suggesting the existence of GBM resistance mechanisms. GBM cells with stem-like properties (C...

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Bibliographic Details
Main Authors: Paul A. Clark, Mari Iida, Daniel M. Treisman, Haviryaji Kalluri, Sathyapriya Ezhilan, Michael Zorniak, Deric L. Wheeler, John S. Kuo
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800170

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http://www.sciencedirect.com/science/article/pii/S1476558612800170

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