Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors

Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors

Abstract A new series of arylmethylene hydrazine derivatives bearing 1,3-dimethylbarbituric moiety 7a–o were designed, synthesized, and evaluated for their in vitro urease inhibitory activity. All the title compounds displayed high anti-urease activity, with IC50 values in the range of 0.61 ± 0.06–4...

Full description

Bibliographic Details
Main Authors: Keyvan Pedrood, Homa Azizian, Mohammad Nazari Montazer, Maryam Mohammadi‐Khanaposhtani, Mohammad Sadegh Asgari, Mehdi Asadi, Saeed Bahadorikhalili, Hossein Rastegar, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90104-x

Internet

https://doi.org/10.1038/s41598-021-90104-x

Similar Items