Stress-Based High-Throughput Screening Assays to Identify Inhibitors of Cell Envelope Biogenesis

The structural integrity of the Gram-negative cell envelope is guarded by several stress responses, such as the σ<sup>E</sup>, Cpx and Rcs systems. Here, we report on assays that monitor these responses in <i>E. coli</i> upon addition of antibacterial compounds. Interestingly...

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Bibliographic Details
Main Authors: Maurice Steenhuis, Corinne M. ten Hagen-Jongman, Peter van Ulsen, Joen Luirink
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/9/11/808