RBC Adherence of Immune Complexes Containing Botulinum Toxin Improves Neutralization and Macrophage Uptake

RBC Adherence of Immune Complexes Containing Botulinum Toxin Improves Neutralization and Macrophage Uptake

In the paralytic disease botulism, the botulinum neurotoxin (BoNT) passes through the bloodstream to reach and inactivate neuromuscular junctions. Monoclonal antibodies (mAbs) may be useful BoNT countermeasures, as mAb combinations can rapidly clear BoNT from the blood circulation. We have previousl...

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Bibliographic Details
Main Authors: Fetweh H. Al-Saleem, Rashmi Sharma, Rama Devudu Puligedda, Md. Elias, Chandana Devi Kattala, Paul M. Simon, Lance L. Simpson, Scott K. Dessain
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Toxins
Subjects:
biodistribution
botulinum toxin
clearance
immune complex
macrophage activation
mechanism
monoclonal antibody
neutralization
pharmacokinetic
red blood cell
Online Access:http://www.mdpi.com/2072-6651/9/5/173

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http://www.mdpi.com/2072-6651/9/5/173

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